Activation of meiosis and sporulation by repression of the RME1 product in yeast
- 1 February 1986
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 319 (6056) , 738-742
- https://doi.org/10.1038/319738a0
Abstract
The abilit of the yeast Saccharomyces cerevisiae to enter meiosis and sporulate is conferred by the a1-.alpha.2 regulatory activity of the mating-type locus. We have cloned that the RME1 gene and show that: the RME1 transcript is repressed by a1-.alpha.2 in a/.alpha. cells; overexpression of the RME1 product in a/.alpha. cells blocks sporulation; and inactivation of RME1 by a null mutation constructed in vitro permits cells lacking a1-.alpha.2 activity to sporulate. The RME1 product thus inhibits meiosis; the mating-type locus permits entry into meiosis by repression of RME1.This publication has 39 references indexed in Scilit:
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