STRENGTH OF CALLUS IN FRACTURED HUMERUS OF RAT TREATED WITH ANTI-ANABOLIC AND ANABOLIC COMPOUNDS

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Abstract
Anti-anabolic action of a lathyrus factor (BAPN) and of cortisone and anabolic action of androgenic steroids Dianabol (17α-methyl-17β-hydroxy-androsta-1,4-dien-3-one) and Ora-Testryl (9α-fluoro-11β-hydroxy-17α-methyltestosterone) on the healing of fractured humeri in rats was investigated. Tensile strength of healing callus measured at 1st, 2nd and 3rd week after fracture was determined to assess the difference in action between the compounds studied. Healing bones were also studied histologically. Significant decrease of tensile strength of callus was observed in BAPN treated rats at 2nd and 3rd week after fracture. Less marked decrease was noted in cortisone treated animals. Certain delay of new bone formation was notable, histologically, in callus of animals treated with anti-anabolic compounds. Both androgens studied were found to increase significantly tensile strength of callus at 1st and 2nd week after fracture. Increase of tensile strength was associated with marked stimulation of new bone formation and calcification of callus, observed on histological preparations.