The influence of anaesthetic agents on the formation of methaemoglobin induced by aniline in cats

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Abstract
Administration of anaesthetic agents modifies the methaemoglobin formation induced by aniline in cats. The maximum amount of methaemoglobin is reduced, so too is the rate at which the methaemoglobin disappears. Studies with phenylhydroxylamine indicate that these changes are due to anaesthetics modifying the metabolism of aniline to phenylhydroxylamine rather than modifying the action of phenylhydroxylamine on systems within the red blood cell. The microsomal metabolism inhibitor SKF 525A has no effect on methaemoglobin formation induced by aniline.