Microbial Transformations of Natural Antitumor Agents. 9. O-Demethylation of 9-Methoxyellipticine
- 1 November 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 42 (6) , 643-647
- https://doi.org/10.1021/np50006a010
Abstract
Microbial transformation studies were conducted with 9-methoxyellipticine (1). Several microorganisms including Botrytis allii (NRRL 2502), Cunninghamella echinulata (NRRL 1386), C. echinulata (NRRL 3655) and Penicillium brevicompactum (ATCC 10418) achieved O-demethylation of (1) in good yield. P. brevicompactum was used to prepare 9-hydroxyellipticine (4) from 1 for isolation and complete identification. High-performance liquid chromatography verified the identity of the major metabolite (4) in other cultures.This publication has 9 references indexed in Scilit:
- MICROBIAL TRANSFORMATIONS OF NATURAL ANTI-TUMOR AGENTS .8. FORMATION OF 8-HYDROXYELLIPTICINES AND 9-HYDROXYELLIPTICINES1979
- Microbial Transformations of Natural Antitumor Agents: O -Demethylation of Vindoline by Sepedonium chrysospermumAntimicrobial Agents and Chemotherapy, 1978
- COMPARATIVE PHYSIOLOGICAL DISPOSITION OF ELLIPTICINE IN SEVERAL ANIMAL SPECIES AFTER INTRAVENOUS ADMINISTRATION1978
- CHARACTERIZATION OF METABOLITES OF ELLIPTICINE IN RAT BILE1978
- The hydroxylation of the antitumor agent, ellipticine, by liver microsomes from differently pretreated ratsBiochemical Pharmacology, 1977
- Microbial transformations of glaucineJournal of the Chemical Society, Perkin Transactions 1, 1977
- Microbial Models of Mammalian MetabolismO-Demethylations of PapaverineXenobiotica, 1977
- Bacterial attack on phenolic ethers: An enzyme system demethylating vanillic acidBiochemical Journal, 1967
- The demethylation of griseofulvin by fungiBiochemical Journal, 1961