HLA Antigens on Red Blood Cells

Publisher Website
Google Scholar
Abstract
Exceptionally strong HLA reactivity of red blood cells (RBC) of 2 healthy blood donors, concerning several HLA antigens was shown. HLA antigens not usually detectable on RBC were also expressed on RBC of these donors. The RBC showed a broad spectrum of reactivity with sera containing HLA antibodies. Absorption/elution experiments with these RBC and HLA antisera proved successful. Absorption studies with leukocytes showed that HLA-A2 and A28 behave as separate specificities also on RBC, even though antisera always seemed to contain hemagglutinins that reacted with both. No evidence was found that HLA is associated with .beta.2-microglobulin on the RBC membrane.