Differential effect of silybin on the Fe2+-ADP and t-butyl hydroperoxide-induced microsomal lipid peroxidation
- 1 February 1986
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 42 (2) , 139-141
- https://doi.org/10.1007/bf01952435
Abstract
Summary We have observed a differential effect of silybin dihemisuccinate on rat liver microsonal oxygen consumption and on lipid peroxidation induced by NADPH-Fe2+-ADP and t-butyl hydroperoxide. These results are ascribed to the antioxidant properties of the flavonoid. The differences observed in the effect of the catalysts may be a consequence of the different capacity of silybin to act as a scavenger of free radicals formed by NADPH-Fe2+-ADP or t-butyl hydroperoxide.Keywords
This publication has 11 references indexed in Scilit:
- Assessment of the scavenging action of reduced glutathione, (+)-cyanidanol-3 and ethanol by the chemiluminescent response of the xanthine oxidase reactionCellular and Molecular Life Sciences, 1983
- The Nature of the Primary Oxidants in Oxidations Mediated by Metal IonsPublished by Elsevier ,1982
- Ultraweak chemiluminescence: a sensitive assay for oxidative radical reactions.1981
- Singlet oxygen production associated with hydroperoxide induced lipid peroxidation in liver microsomesBiochemical and Biophysical Research Communications, 1978
- Spin-trapping studies of hydroxyl radical production involved in lipid peroxidationArchives of Biochemistry and Biophysics, 1978
- Inhibitory action of silymarin of lipid peroxide formation in rat liver mitochondria and microsomesBiochemical Pharmacology, 1977
- Silymarin — ein Hemmstoff der MeerrettichperoxidaseCellular and Molecular Life Sciences, 1977
- ADP-activated lipid peroxidation coupled to the TPNH oxidase system of microsomesBiochemical and Biophysical Research Communications, 1963
- Interaction of ascorbic acid and mitochondrial lipidesArchives of Biochemistry and Biophysics, 1959
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951