A Monoclonal Antibody with Selectivity for Human Kappa Myeloma and Lymphoma Cells which has Potential as a Therapeutic Agent
- 1 January 1985
- book chapter
- Published by Springer Nature
- Vol. 186, 833-841
- https://doi.org/10.1007/978-1-4613-2463-8_101
Abstract
K-1-21 is a monoclonal antibody which binds to human free kappa light chains and recognises a determinant, KMA selectively expressed on kappa myeloma and lymphoma cells. KMA is absent on plasma cells and resting B cells from normal adults but can be detected on some foetal B cells and a small proportion of activated B cells. Expression of KMA is greatest on cycling cells. K-1-21 is an IgG1 antibody that elicits ADCC but will not cap the KMA determinant unless a second ligand is present. K-1-21 has potential for practical application.Keywords
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