Molecular Diagnosis of the Philadelphia Chromosome in Acute Lymphoblastic Leukemia
- 1 January 1989
- journal article
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 1 (1) , 3-10
- https://doi.org/10.3109/10428198909042452
Abstract
The Philadelphia (Ph(1)) chromosome was the first specific chromosomal abnormality to be consistently associated with a particular neoplasm, in this case chronic myelogenous leukemia (CML,)(1). Formed by a reciprocal translocation between chromosomes 9 and 22(2), the 22q-, or Ph(1) chromosome is found in the malignant cells of more than 90% of patients with CML(3). The presence of the molecular equivalent of a Ph(1) chromosome is such a consistent finding in CML that it IS now the basis of a diagnostic test in routine clinical use.Keywords
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