Reproducibility of high spatial resolution proton magnetic resonance spectroscopic imaging in the human brain
- 1 April 1996
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 35 (4) , 606-610
- https://doi.org/10.1002/mrm.1910350422
Abstract
The application of proton (1H) magnetic resonance spectroscopic imaging (MRSI) allows for noninvasive, localized analyses of brain biochemistry; however, minimal work has been devoted to the evaluation of 1H MRSI reproducibility. This study examined the reproducibility of 1H MRSI from five normal subjects on two occasions, separated by 10 days. Reproducibility of the MR signal was evaluated in the context of automated shimming, automated processing, and accurate subject repositioning. Reliability measures for physicochemical indices (choline moieties, creatine, N-acetylaspartate, and myo-inositol) were moderately concordant across repeat studies. Gain variation and repositioning results were excellent. It has been concluded that 1H MRSI reproducibility is adequate for serial studies of brain metabolism.Keywords
This publication has 11 references indexed in Scilit:
- Short TE hydrogen‐1 spectroscopic MR imaging of normal human brain: Reproducibility studiesJournal of Magnetic Resonance Imaging, 1994
- Development of the human brain: In vivo quantification of metabolite and water content with proton magnetic resonance spectroscopyMagnetic Resonance in Medicine, 1993
- Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy.Radiology, 1993
- Energy Reserves and Utilization Rates in Developing Brain Measured in vivo by 31P and 1H Nuclear Magnetic Resonance SpectroscopyJournal of Cerebral Blood Flow & Metabolism, 1993
- Cerebral Acid Buffering Capacity at Different Ages Measured In Vivo by 31P and 1H Nuclear Magnetic Resonance SpectroscopyJournal of Neurochemistry, 1992
- Inhomogeneity correction for in vivo spectroscopy by high‐resolution water referencingMagnetic Resonance in Medicine, 1992
- Proton nuclear magnetic resonance spectroscopy measurements of methylene and methyl line widths in plasma: Significant variations with extent of breast cancer, duration of pregnancy and agingNMR in Biomedicine, 1991
- Rapid in vivo proton shimmingMagnetic Resonance in Medicine, 1991
- Information from combined 1H and 31P NMR studies of cell extracts: Differences in metabolism between drug-sensitive and drug-resistant MCF-7 human breast cancer cellsBiochemical and Biophysical Research Communications, 1990
- On various intraclass correlation reliability coefficients.Psychological Bulletin, 1976