DISTRIBUTION OF RADIOMERCURY ADMINISTERED AS LABELLED CHLORMERODRIN (NEOHYDRIN®) IN THE KIDNEYS OF RATS AND DOGS 1

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Abstract
Chlormerodrin labeled with Hg203 was administered intramuscularly to rats in amounts ranging from 0.1 mg to 20 mg Hg/kg body weight. Fractions of sucrose suspended kidney homogenate were obtained by differential centrifugation. The highest concentration of Hg was in the soluble fraction. Hg was also present in granules which could not be removed by repeated washing. Dogs were sacrificed at the time of maximum diuresis by the labeled chlormerodrin. The highest concentration of Hg was found in the outer renal cortex, with diminishing radioactivity as the medullary papillae were approached. The intracellular distribution of Hg in dog kidney homogenates resembled that in rat kidney.