Insulin binding in denervated muscle
- 1 March 1986
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 9 (3) , 211-215
- https://doi.org/10.1002/mus.880090304
Abstract
Insulin binding was measured in rat muscle following denervation. There was a 40% reduction in the number of high‐affinity insulin receptors, with no change in the insulin binding Kd. Selected muscles showed a 40%–60% reduction in weight during this period. The down regulation in the number of insulin receptors may contribute to the mechanism of muscle atrophy following denervation.This publication has 22 references indexed in Scilit:
- Muscle pyruvate oxidation following denervation and reinnervationMuscle & Nerve, 1983
- Inhibition of insulin-stimulated xylose uptake in denervated rat soleus muscle: a post-receptor effectDiabetologia, 1982
- Normal function in sarcoplasmic reticulum from mice with muscular dystrophyMuscle & Nerve, 1982
- Characterization of insulin binding to skeletal muscle sarcolemma during the development of diabetesExperimental Neurology, 1981
- A possible role for glucocorticoids in denervation atrophyMuscle & Nerve, 1981
- Mobilization of subcutaneously injected tritiated insulin in rats: Effects of muscular exerciseDiabetologia, 1978
- Inhibition of mitochondrial Mg2+ ATPase activity in isolated perfused rat liver by keponeBiochemical Pharmacology, 1977
- Binding of insuling and other hormones to non-receptor materials: Saturability, specificity and apparent “negative cooperativity”Biochemical and Biophysical Research Communications, 1975
- Isolation of plasma membrane from cardiac muscleBiochemical and Biophysical Research Communications, 1971
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949