Thromboembolic Accidents in Patients with Congenitial Deficiency of Factor XII
- 1 January 1974
- journal article
- letter
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 31 (03) , 525-526
- https://doi.org/10.1055/s-0038-1649195
Abstract
A reduction in circulating factor XII could play a part in thromboembolic accidents of patients with congenital deficiency of Hageman factor, since a plasmatic factor is diminished which has antiaggregating activity for the platelets. Factor XII may have an important role as an inhibitor of platelet aggregation quite independently of the well known coagulant and fibrinolytic activities. Having activated the formation of the 1st fibrin factor XII may intervene in the regulation of the progress of a thrombus by both its fibrinolytic and platelet aggregation inhibiting activities.This publication has 5 references indexed in Scilit:
- Effect of Contact Factor (Factor XII + Factor XI) on Aggregation of PlateletsPathophysiology of Haemostasis and Thrombosis, 1974
- Circulating Anticoagulant Against Factors XI and XII Together with Massive Spontaneous Platelet AggregationScandinavian Journal of Haematology, 1973
- RECURRENT THROMBOSIS IN A YOUNG WOMAN WITH A CIRCULATING ANTICOAGULANT DIRECTED AGAINST FACTORS XI AND XIIActa Medica Scandinavica, 1972
- The Demise of John HagemanNew England Journal of Medicine, 1968