Synthesis and Metabolism of Tritium-Labeled DL-Kynurenine.
- 1 March 1958
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 97 (3) , 568-571
- https://doi.org/10.3181/00379727-97-23807
Abstract
DL-Kynurenine was labeled with tritium by the Wilzbach procedure. Intraperitoneal injection of tritium-labeled DL-kynurenine into rats was followed by the excretion of labeled quinolinic acid and N1-methyl -nicotinamide in the urine. The evidence is definite that kynurenine can serve as a precursor of quinolinic acid and N -methylnicotinamide. During 24 hours after injection of 1 mg of labeled DL-kynurenine, 6.86% was excreted as unchanged labeled kynurenine.Keywords
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