WAX D PEPTIDO-GLYCOLIPID OF MYCOBACTERIUM TUBERCULOSIS - FURTHER PURIFICATION AND STUDY OF AND STUDY OF AN ADJUVANT ARTHRITIS-INHIBITING SUBFRACTION
- 1 January 1968
- journal article
- research article
- Vol. 14 (2) , 159-+
Abstract
Waxes-D from M. tuberculosis var. hominis, strains Canetti and Brevannes, and from M. kansasii No. 21 which are macromolecular peptido-glycoliplds with important biological properties (Freund''s adjuvant effect; induction of adjuvant arthritis) were submitted to further purifications. The fractions obtained after ultracentrifugation in ether were acetylated and chromatographed on silicic acid. The quantitative amino-acid compositions of the different subtractions were established. The study of these compounds seemed important as the arthritis-inducing ability of wax-D was lost after acetylatioa. Furthermore, rats injected with an acetylated wax-D were protected against the arthritis-inducing ability of unaltered wax-D.This publication has 9 references indexed in Scilit:
- ROLE OF ADJUVANTS IN THE PRODUCTION OF DELAYED HYPERSENSITIVITYBritish Medical Bulletin, 1967
- FRACTIONATION AND CHARACTERIZATION OF WAX D, A MACROMOLECULAR PEPTIDOGLYCOLIPID OF MYCOBACTERIUM TUBERCULOSIS. I. BIOCHEMICAL INVESTIGATIONS OF WAX D OF HUMAN STRAIN H37RA.1965
- CORRELATION OF ADJUVANT ACTIVITY + CHEMICAL STRUCTURE OF WAX D FRACTIONS OF MYCOBACTERIA1964
- Isolement de fractions peptido-glycolipidiques à partir des cires d de mycobactéries bovines, atypiques, aviaires et saprophytesBiochimica et Biophysica Acta, 1963
- Analytical studies on wax D, a macromolecular peptidoglycoplied fraction from humn strains of Mycobacterium tuberculosos.1962
- STUDIES OF ARTHRITIS AND OTHER LESIONS INDUCED IN RATS BY INJECTION OF MYCOBACTERIAL ADJUVANT .2. EVIDENCE THAT THE DISEASE IS A DISSEMINATED IMMUNOLOGIC RESPONSE TO EXOGENOUS ANTIGEN1960
- The influence of components of M. tuberculosis and other Mycobacteria upon antibody production to ovalbumin.1958
- The mode of action of immunologic adjuvants.1956