CAUSE OF INCREASED HEIDENHAIN POUCH SECRETION AND SERUM GASTRIN CONCENTRATION AFTER GASTROJEJUNOSTOMY IN DOGS - WITH A STATISTICAL APPENDIX

  • 1 January 1977
    • journal article
    • research article
    • Vol. 73  (5) , 1065-1071
Abstract
In 10 dogs with Heidenhain pouches (HP), a gastrojejunostomy (GEA) was constructed and later converted into a Roux en-Y anastomosis in order to abolish or reduce transstomal reflux. Duodenal inhibition was then abolished by duodenal transection, and finally the duodenal bulb was excised. Twenty-four h HP acid output increased after GEA, 70% of the increase attributable to transstomal reflux, the rest to decreased duodenal inhibition. Abolished duodenal inhibition caused a new rise, not significantly different from that caused by the combined effect of reflux and decreased duodenal inhibition after GEA. Twenty-four h fasting HP acid output and 5 h food-stimulated HP acid output rose after GEA by the same amount as that caused by abolished duodenal inhibition. A significant correlation was found between integrated gastrin and total HP acid output after food stimulation. Fasting and food-stimulated gastrin concentration rose after GEA, the latter caused by reflux alone. Elimination of duodenal inhibition caused an unexpected rise in fasting and food-stimulated gastrin concentration.

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