Lipoprotein is a predominant Toll-like receptor 2 ligand in Staphylococcus aureus cell wall components
Open Access
- 22 December 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in International Immunology
- Vol. 18 (2) , 355-362
- https://doi.org/10.1093/intimm/dxh374
Abstract
Lipoteichoic acid (LTA) derived from Staphylococcus aureus is reported to be a ligand of Toll-like receptor 2 (TLR2). In this study, we demonstrated that lipoproteins obtained from S. aureus are potent activators of TLR2. A fraction obtained by Triton X-114 phase partitioning activated cells through TLR2. The fraction contained proteins and LTA. The activity was detected in compounds in a mass range of 12–40 kDa. Proteinase K digested the active compounds into lower molecular weight active materials S. aureus cell wall components.Keywords
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