Activation of forebrain dopamine systems by phencyclidine and footshock stress: evidence for distinct mechanisms
- 1 September 1987
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 93 (1) , 133-135
- https://doi.org/10.1007/bf02439600
Abstract
Phencyclidine combined with footshock stress produced a greater increase in the homovanillic acid content of prefrontal cortex than either phencyclidine or footshock alone. Phencyclidine decreased both substance P and substance K in the ventral tegmental area. The results suggest that phencyclidine and footshock activate forebrain dopaminergic systems in part by separate mechanisms.Keywords
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