Clinical Implications of Isoniazid Blood Levels in Pulmonary Tuberculosis

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Abstract
ORALLY administered isoniazid is converted to various metabolic derivatives in the human body. Isoniazid hydrazones, acetylated isoniazid, isonicotinic acid and isonicotinic acid conjugates, in addition to free unmetabolized isoniazid, have been found in the urine of human subjects given a single oral test dose of isoniazid.1 This metabolic alteration is so extensive in some cases that as little as 1 per cent of a test dose of the drug may be excreted in the urine free and unaltered, and as much as 60 per cent of a dose may be excreted in the acetylated form. Only the free drug, however, . . .