Power of different sampling strategies to detect quantitative trait loci variance effects
- 1 March 1992
- journal article
- Published by Springer Nature in Theoretical and Applied Genetics
- Vol. 83 (5) , 582-588
- https://doi.org/10.1007/bf00226901
Abstract
Many studies have shown that segregating quantitative trait loci (QTL) can be detected via linkage to genetic markers. Power to detect a QTL effect on the trait mean as a function of the number of individuals genotyped for the marker is increased by selectively genotyping individuals with extreme values for the quantitative trait. Computer simulations were employed to study the effect of various sampling strategies on the statistical power to detect QTL variance effects. If only individuals with extreme phenotypes for the quantitative trait are selected for genotyping, then power to detect a variance effect is less than by random sampling. If 0.2 of the total number of individuals genotyped are selected from the center of the distribution, then power to detect a variance effect is equal to that obtained with random selection. Power to detect a variance effect was maximum when 0.2 to 0.5 of the individuals selected for genotyping were selected from the tails of the distribution and the remainder from the center.Keywords
This publication has 25 references indexed in Scilit:
- Mapping quantitative trait loci using molecular marker linkage mapsTheoretical and Applied Genetics, 1990
- (TG)n uncovers a sex-specific hybridization pattern in cattleGenomics, 1990
- Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphismsNature, 1988
- Mapping and analysis of quantitative trait loci in Lycopersicon (tomato) with the aid of genetic markers using approximate maximum likelihood methodsHeredity, 1987
- Molecular Marker‐Facilitated Investigations of Quantitative Trait Loci in Maize. II. Factors Influencing Yield and its Component Traits1Crop Science, 1987
- Trait-based analyses for the detection of linkage between marker loci and quantitative trait loci in crosses between inbred linesTheoretical and Applied Genetics, 1987
- Hypervariable ‘minisatellite’ regions in human DNANature, 1985
- Restriction fragment length polymorphisms in genetic improvement: methodologies, mapping and costsTheoretical and Applied Genetics, 1983
- Genetic polymorphism in varietal identification and genetic improvementTheoretical and Applied Genetics, 1983
- Use of naturally-occurring enzyme variation to detect and map genes controlling quantitative traits in an interspecific backcross of tomatoHeredity, 1982