Enzymatic resolution of 1‐ferrocenylethanol and 1‐ferrocenyl‐2,2,2‐trifluoroethanol using lipases

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Abstract
1‐Ferrocenylethanol and 1‐ferrocenyl‐2,2,2‐trifluoroethanol were resolved with transesterification by lipases to the optically active (R)‐esters and (S)‐alcohols. Enzymatic hydrolysis of the racemic esters of 1‐ferrocenylethanol using lipases yielded (R)‐alcohol and (S)‐esters. Enantioselective hydrolysis of racemic acetate or butanoate of 1‐ferrocenyl‐2,2,2‐trifluoroethanol yielded the (S)‐alcohol and (R)‐esters. Enzymatic hydrolysis of (±)‐acetate of 1‐ferrocenyl‐2,2,2‐trifluoroethanol yielded (R)‐alcohol and (S)‐acetate, but the equivalent (±)‐butanoate was not hydrolyzed.