Further studies on the inhibition of acetate metabolism by propionate

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Abstract
The production of C14O2 from carboxyl-labeled acetate by rat-liver homoganates was almost completely abolished by propionate in only 1/10 of the concentration of the acetate. Butyrate was a less powerful inhibitor of oxidation of acetate. The oxidation of (2-C14) pyruvate was affected to a much smaller extent by propionate, although the incorporation of isotope into acetoacetate was largely suppressed. Oxidation of acetate was strongly inhibited by propionate in sheep-liver homogenates; in pigeon-liver homogenates the inhibition was much less. The oxidation of propionate by rat-liver homogenates was much slower than its oxidation by sheep- or pigeon-liver homogenates. The acetylation of sulfanilamide by a rat-liver extract, together with an acetone fraction of pigeon-liver containing the amine-acetylating enzyme, was inhibited to only a relatively small extent by propionate. The very low rate of oxidation of acetate by rat-liver homogenates in the presence of propionate was increased by the addition of coenzyme A.

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