Uromodulin: A Unique 85-Kilodalton Immunosuppressive Glycoprotein Isolated from Urine of Pregnant Women

Open Access

2 August 1985

journal article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 229 (4712) , 479-481
https://doi.org/10.1126/science.2409603

Abstract

Crude fractions of urine from pregnant women are immunosuppressive in vitro. An 85-kilodalton immunosuppressive glycoprotein purified to homogeneity from such urine inhibited in vitro assays of human T-cell and monocyte activity at concentrations of 10(-9) to 10(-11) molar. This material was nontoxic and blocked early events required for normal T-cell proliferation in vitro. On the basis of its tissue source and its in vitro activity, the name "uromodulin" is proposed for this glycoprotein.

Keywords

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