Preferential Transmission of the Z Deficient Allele of α 1 -Antitrypsin
- 27 July 1979
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 205 (4404) , 407-408
- https://doi.org/10.1126/science.313077
Abstract
The transmission of the Z deficient allele of α 1 -antitrypsin was studied in 23 families, each with a single parent heterozygous for this allele. When the mother carried the Z allele, the distribution of phenotypes in the children did not differ significantly from the expected frequency. In contrast, when the father was the carrier, a significant increase of heterozygous phenotypes was observed in the children. This observation suggests that a selective advantage is associated with the expression of the Z allele in male gametes.Keywords
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