t‐Butyl‐4‐hydroxyanisole, a novel respiratory chain inhibitor
- 20 January 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 195 (1-2) , 295-297
- https://doi.org/10.1016/0014-5793(86)80180-6
Abstract
t‐Butyl‐4‐hydroxyanisole, an antioxidant food additive, inhibited the growth of Trypanosoma cruzi by almost 100% at 0.5 mM concentration. This compound inhibited 70% of oxygen consumption of epimastigotes. The redox level of NAD(P) was shifted to a more reduced state and inversely the redox level ofcytochrome b changed to a more oxidized state. This hydroxyanisole thus is a new electron transport chain inhibitor. This compound and related ones, or the respiratory chain of T. cruzi, may be important in the design of antichagasic drugs.Keywords
This publication has 8 references indexed in Scilit:
- FREE RADICAL INTERMEDIATES IN THE TRYPANOCIDAL ACTION OF DRUGS AND PHAGOCYTIC CELLSPublished by Walter de Gruyter GmbH ,1984
- Electrogenic sodium pumping in Mytilus smooth muscleComparative Biochemistry and Physiology Part A: Physiology, 1980
- Effect of inhibitors of electron transport and oxidative phosphorylation on trypanosoma cruzi respiration and growthMolecular and Biochemical Parasitology, 1980
- Hydroperoxides can modulate the redox state of pyridine nucleotides and the calcium balance in rat liver mitochondriaProceedings of the National Academy of Sciences, 1979
- Epoxide hydrase in Trypanosoma cruzi epimastigotesBiochimica et Biophysica Acta (BBA) - General Subjects, 1979
- Cytochrome P-450 and Drug Metabolism in Trypanosoma cruzi : Effects of PhenobarbitalScience, 1976
- Toxicology and biochemistry of butylated hydroxyanisole and butylated hydroxytolueneJournal of Oil & Fat Industries, 1975
- Metabolic Fate in Animals of Hindered Phenolic Antioxidants in Relation to their Safety Evaluation and Antioxidant FunctionPublished by Elsevier ,1966