Catecholamines in Ulcer Provocation

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Abstract
Local and systemic factors are involved in stress ulceration. In the local gastric environment, acid and pepsin secretion,1 mucus secretion,2 vascular alterations,3 and cellular resistance are important. Systemically, the stimulation of the central nervous system,4 corticosteroid secretion,5 and the presence of high levels of catecholamines and possibly tryptamines may play an important role in the genesis of stress ulceration. This study was designed to reproduce and to investigate the ulcerogenic role of two factors that are present during stress: increased gastric secretion and increased levels of catecholamines. Methods In the first portion of this experiment, 71 adult mongrel dogs and 21 adult cats were used. A No. 90 polyethylene catheter was tied into the left gastric artery and brought out to a subcutaneous position so that epinephrine could be injected with ease. Dilute heparin in 0.9% sodium chloride solution was used to maintain patency of the catheters.

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