Botulism and guanidine. Ten years later

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Abstract
Guanidine hydrochloride was introduced as an adjunct in the treatment of botulism in 1968. It was reported to be of benefit in 39 cases and of no benefit in 13 cases. No serious side effects occurred with the short-term therapy required in botulism. The 2 cases are similar to earlier cases in that the improvement seen with guanidine therapy is most notable in ocular muscles and least notable in respiratory muscles. Electrophysiological finding again showed an increase in the amplitude of evoked muscle action potentials after guanidine administration.

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