FREEZE DRYING OF A FROZEN LIQUID IN A PHIAL

Publisher Website
Google Scholar
Abstract
A sorption-sublimation mathematical model for a freeze dryer is presented, and is used to investigate the design and operation of a freeze dryer, in which a frozen liquid enclosed in a phial is dried. With the material chosen, it was found that the best operating condition would correspond to minimum chamber inert gas pressure. The most desirable design of dryer appears to be one in which moderate but consistent resistances to heat transfer are incorporated, so that the heat flux program of the lower heating plate could be optimized by operating at a higher temperature, either under feedback or preprogrammed feedforward controllers.