Quantitative analysis on isolated organs of the autonomic blocking properties of indoramin hydrochloride (Wy 21901)

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Abstract
1 Indoramin is a competitive α-adrenoceptor blocking agent on the guinea-pig isolated vas deferens and aortic strip; the pA2 value on the aorta is 7·4. 2 Indoramin is devoid of β-adrenoceptor blocking activity on the guinea-pig isolated trachea (10–4m) and the Langendorff preparation of the rabbit heart (10−6m). It also has no adrenergic neurone blocking action on the Finkleman preparation of the rabbit small intestine (10−5m). 3 On the Langendorff preparation of the rabbit isolated heart, indoramin (above 10−6m) has cardio-inhibitory properties similar to those of propranolol. 4 On the guinea-pig isolated ileum (10−5m) and trachea (10−6m), indoramin is devoid of anticholinergic activity, but has a potent antihistamine action which satisfies the criteria for competitive antagonism; the pA2 value for this antagonism on the ileum is 8·2. 5 Indoramin antagonizes 5-hydroxytryptamine on the rat isolated fundus and ileum; the pA2 value for the antagonism on the ileum is 60.

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