Predictive Factors of Mortality Due to Polymicrobial Peritonitis With Candida Isolation in Peritoneal Fluid in Critically Ill Patients

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Abstract
FUNGAL ISOLATES in the intensive care unit (ICU) represent almost 17% of all nosocomial infections, but only half of these patients receive antifungal therapy in current practice.1 Mortality due to severe intra-abdominal infection remains as high as 40%, despite improvement in intensive care.2 Mortality related to candidemia has been clearly established,3 but the pathogenicity of yeasts in peritoneal fluid remains unclear.4 In 3 series performed on a limited number of patients, overall mortality due to yeast peritonitis was as high as 62% to 75%.2,5,6 Practice guidelines for the treatment of candidiasis have also been recently published.7 In intra-abdominal infections, antifungal therapy has been recommended for peritoneal catheter dialysis infections, peritonitis related to intra-abdominal leakage of fecal material, and surgical repair and drainage.4,7