Inhibition of herpesvirus multiplication in guinea pig skin by antiviral compounds
- 1 June 1980
- journal article
- research article
- Published by Springer Nature in Archiv für die gesamte Virusforschung
- Vol. 65 (2) , 149-156
- https://doi.org/10.1007/bf01317326
Abstract
The effects of adenine arabinoside, cytosine arabinoside, iododeoxyuridine, ribavirin, phosphonoacetate and phosphonoformate on virus titers in cutaneous herpesvirus infections of guinea pigs have been determined and compared to their effects on lesion score. Only phosphonoacetate and phosphonoformate caused a reduction in virus titer and lesion score when the drugs were applied topically after symptoms had developed. However, unlike phosphonoacetate, phosphonoformate did not cause local skin irritation. A herpesvirus mutant, inducing a DNA polymerase resistent to phosphonoformate gave rise to an infection in which the virus titer was not reduced by phsophonoformate.Keywords
This publication has 12 references indexed in Scilit:
- Latent infections of sensory ganglia as influenced by phosphonoformate treatment of herpes simplex virus-induced skin infections in hairless miceAntimicrobial Agents and Chemotherapy, 1979
- Characteristics of Herpesvirus Mutants Resistant to Phosphonoformate and PhosphonoacetateAntimicrobial Agents and Chemotherapy, 1979
- Latent Herpes Simplex Virus Infections in Sensory Ganglia of Hairless Mice Prevented by AcycloguanosineAntimicrobial Agents and Chemotherapy, 1979
- The Natural History of Recurrent Facial-Oral Infection with Herpes Simplex VirusThe Journal of Infectious Diseases, 1978
- Comparison of the therapeutic effects of five antiviral agents on cutaneous herpesvirus infection in guinea pigsArchiv für die gesamte Virusforschung, 1978
- Therapeutic Effect of Trisodium Phosphonoformate on Cutaneous Herpesvirus Infection in Guinea PigsAntimicrobial Agents and Chemotherapy, 1978
- The activity of iododeoxyuridine, adenine arabinoside, cytosine arabinoside, ribavirin and phosphonoacetic acid against herpes virus in the hairless mouse modelJournal of Antimicrobial Chemotherapy, 1977
- Phosphonoacetic Acid-Resistant Herpes Simplex Virus Infection in Hairless MiceAntimicrobial Agents and Chemotherapy, 1975
- Guinea Pig Model for Cutaneous Herpes Simplex Virus InfectionJournal of Investigative Dermatology, 1974
- Beitrag zur Kenntnis der organischen PhosphorverbindungenBerichte der deutschen chemischen Gesellschaft (A and B Series), 1924