Mammalian Respiratory Mucociliary Clearance
- 1 December 1973
- journal article
- research article
- Published by Taylor & Francis in Archives of environmental health
- Vol. 27 (6) , 364-369
- https://doi.org/10.1080/00039896.1973.10666403
Abstract
An in vivo model was designed to provide information on the major factors affecting mammalian mucociliary clearance. It involves simultaneous quantitation of mucous load, tracheal transport velocity, ciliary beat frequency, and rheological properties of mucus. Values in 23 cats were obtained. The results were remarkably consistent for the group as well as for individual cats that were reexamined. The mucous blanket depth measures usually < 10μ, ciliary beat frequency averages 876±151 beats per minute, and transport rate 10.5±3.7 mm/min. Average mucous viscosity was 248±106 poises at a shear rate of 1 sec-1 and recoverable shear strain (elasticity) 3.1±1.1 units at 100 dynes/sq cm. It is suggested that this model can serve as a sensitive indicator of early deleterious effects of airway pollution or noxious inhalants and pinpoint the initial target area.Keywords
This publication has 6 references indexed in Scilit:
- Physical Properties of SputumAmerican Review of Respiratory Disease, 1972
- Ciliary Motility StudiesArchives of internal medicine (1960), 1970
- Mucus Production and Ciliary Transport Activity In Vivo Studies Using the ChickenArchives of environmental health, 1970
- FLOW INDUCED BY BIOLOGICAL MUCOCILIARY SYSTEMS*Annals of the New York Academy of Sciences, 1966
- CHARACTERIZATION OF PHYSICAL, CHEMICAL AND BIOLOGICAL PROPERTIES OF MUCUS IN THE INTACT ANIMALAnnals of the New York Academy of Sciences, 1966
- PRINCIPLES UNDERLYING CILIARY ACTIVITY IN THE RESPIRATORY TRACT: II. A COMPARISON OF NASAL CLEARANCE IN MAN, MONKEY AND OTHER MAMMALSJAMA Otolaryngology–Head & Neck Surgery, 1934