THE INFLUENCE OF ORALLY ADMINISTERED ALKALI AND ACID ON THE RENAL EXCRETION OF QUINACRINE, CHLOROQUINE AND SANTOQUINE 1
Open Access
- 1 November 1947
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 26 (6) , 1168-1172
- https://doi.org/10.1172/jci101909
Abstract
The oral admn. of NH4C1 increases the renal excretion of quinacrine, chloroquine, and santoquine in individuals who are on a constant maintenance dosage regimen. Changes in renal excretion are reflected in changes in plasma level only when the absolute rate of excretion of the substance is high. This is seen in patients on chloroquine and santoquine where the percentage of renal excretion is high but not with quinacrine where the renal excretion is slight.Keywords
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