Vaccination of mice against malaria with soluble antigens. I. The effect of detergent, route of injection, and adjuvant
- 1 September 1986
- journal article
- research article
- Published by Wiley in Parasite Immunology
- Vol. 8 (5) , 409-414
- https://doi.org/10.1111/j.1365-3024.1986.tb00857.x
Abstract
Summary Mice were vaccinated against lethal blood stage P. yoelii malaria with lysates of parasitised blood prepared in various detergents. Two injections, containing 25 ng of protein, of a Triton X-100 lysate gave optimal protection when injected intraperitoneally with saponin as adjuvant. Such lysates provide a starting point for the isolation of potential antigens for vaccination, selected for their protective activity in vivo.Keywords
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