Experimental Asbestosis in Rats: The Effect of Particle Size and of Added Alumina
Open Access
- 1 June 1951
- Vol. 6 (2) , 127-136
- https://doi.org/10.1136/thx.6.2.127
Abstract
Intratracheal injn. of asbestos dust with and without alumina was carried out in a homogeneous group of 150 young rats. Short fiber (2.5u) asbestos caused only a moderate peribronchial fibrosis; long fiber (15u) asbestos caused a well-marked interstitial fibrosis resembling that seen in human disease. Alumina had no ameliorating effect as shown in silocosis expts., but, in fact, seemed to increase the degree of fibrosis.Keywords
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