THE EFFECT OF VARIOUS AGENTS ON THE BLOOD PRESSURE OF RENAL HYPERTENSIVE DOGS

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Abstract
Renal ischemic hypertension was produced in dogs by bilateral constriction of the renal arteries. Estrone, testosterone, and extracts of liver, pancreas, and garlic and parsley had no significant effect on the blood pressure of the hypertensive animals. Evidence indicates that these agents likewise are effective only psychotherapeutically in essential hypertension in man. Dog renin temporarily increased the blood pressure in renal hypertensive and normal dogs. Renin may have a pathogenetic role in exptl. renal hypertension. Fresh hog kidney by mouth and adrenal cortical extract, whole pituitary extract, and pituitrin parenterally were without effect on the blood pressures of renal hypertensive dogs. The adrenal cortex and the pituitary are apparently not pathogenetically related to exptl. renal hypertension. Distemper lowered the blood pressure of the renal hypertensive dogs but extensive cel-lulitis was without effect. The growing evidence of similarity between exptl. renal ischemic hypertension in the dog and essential hypertension in man was further substantiated.

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