The identification and quantitation of the major metabolites of ethylamphetamine, produced by rabbit liver microsomal preparations
- 1 September 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 29 (1) , 89-95
- https://doi.org/10.1111/j.2042-7158.1977.tb11252.x
Abstract
Amphetamine (I), 1-phenylpropan-2-ol (III), phenylacetone (V), N-hydroxyethylamphetamine (VII), and α-methyl-N-(1′-phenylprop-2′-yl)nitrone (VIII) were obtained as metabolic products from the incubation of ethylamphetamine (II) with fortified male rabbit liver 9000 g supernatant fractions. These metabolites were identified by comparing their t.l.c., g.l.c. and g.l.c.-m.s. behaviour to that of reference compounds. A method for the quantitative analysis of the metabolites in mixtures using g.l.c. techniques is described.This publication has 15 references indexed in Scilit:
- The identification and analysis of the metabolic products of mephentermineJournal of Pharmacy and Pharmacology, 1975
- The metabolism of dibenzylamine: identification of NN-dibenzylhydroxylamine as the major in vitro metabolic product from rabbit fortified hepatic homogenatesJournal of Pharmacy and Pharmacology, 1975
- The Metabolism ofN-Ethyl-N-methylaniline by Rabbit Liver Microsomes: The Measurement of Metabolites by Gas-liquid ChromatographyXenobiotica, 1975
- Synthetic routes to optical isomers of primary and secondary hydroxylamines of 1-arylisopropylaminesTetrahedron, 1975
- Biochemical Mechanisms of Drug ToxicityAnnual Review of Pharmacology, 1974
- The Identification of Four Metabolic Products after Incubation of p -Methoxyamphetamine with Liver Preparations of Various SpeciesXenobiotica, 1974
- Synthesis of N-alkyl-N-hydroxyamphetamines and related nitronesTetrahedron, 1973
- N-ethyl-α-methyl-α-(m-trifluoromethylbenzyl)nitron—the major in vitro metabolic product of fenfluramine in guinea-pig liver microsomal fractionsJournal of Pharmacy and Pharmacology, 1973
- THE IMPORTANCE OF THE ‘HYDROXYLAMINE METABOLIC ROUTE’ IN PHARMACOLOGY, TOXICOLOGY AND PHARMACOKINETICSPublished by Elsevier ,1973
- Determination and identification of amphetamine in urineJournal of Pharmacy and Pharmacology, 1965