Residues of Iindane in plasma and fat of sheep after dipping

Publisher Website
Google Scholar
Abstract
Ten 5–6 year‐old unshorn ewes were dipped in a 0.025% lindane solution. Lindane residues in fat and plasma were analysed by gas liquid chromatography with an electron capture detector. The sensitivity of the method was 0.02 μg/g for fat and 0.005 μg/ml for plasma. Blood samples of 5 sheep were collected up to 84 days. The highest concentration of lindane detected in plasma was 107 ± 37 ng/ml, 48 h after treatment. The disposition of lindane in plasma was studied by linear regression. Omental fat samples were removed by biopsies at 7 or 14 day intervals for 154 days. Fat concentrations of lindane were very high, respectively 30.46 ± 14.6 μg/g, 8.09 ± 4.57 μg/g, and 1.72 ± 0.81 μg/g, 7, 28 and 70 days after dipping. In plasma and fat, the coefficients of elimination calculated by linear regression were similar (0.00190 ± 0.00053 h−1 for plasma, 0.00196 ± 0.00031 h−1 for fat). The tolerance recommended in France (2 μg/g in fat) was obtained 59.7 ± 9.7 days after this treatment.

This publication has 5 references indexed in Scilit: