Immunology's foundation: the 100-year anniversary of the Nobel Prize to Paul Ehrlich and Elie Metchnikoff
Top Cited Papers
- 1 July 2008
- journal article
- review article
- Published by Springer Nature in Nature Immunology
- Vol. 9 (7) , 705-712
- https://doi.org/10.1038/ni0708-705
Abstract
One hundred years ago the birth of immunology was made official by the Nobel Prize award to Elie Metchnikoff and Paul Ehrlich. Metchnikoff discovered phagocytosis by macrophages and microphages as a critical host-defense mechanism and thus is considered the father of cellular innate immunity. Ehrlich described the side-chain theory of antibody formation and the mechanisms of how antibodies neutralize toxins and induce bacterial lysis with the help of complement and thus is considered one of the fathers of humoral adaptive immunity. Despite many discordant discussions in the initial phase after these discoveries, innate and adaptive responses are now known to be complementary partners in producing robust immunity.Keywords
This publication has 15 references indexed in Scilit:
- The clonal selection theory: 50 years since the revolutionNature Immunology, 2007
- Allergy and ImmunologyAnnual Review of Medicine, 1957
- A Theory of the Structure and Process of Formation of Antibodies*Journal of the American Chemical Society, 1940
- Chemische Untersuchung des Präzipitates aus Hämoglobin und Anti-Hämoglobin-Serum und Bemerkungen über die Natur der Antikörper.Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1930
- The Nature of Man: Studies in Optimistic Philosophy.The Philosophical Review, 1904
- Experimentelle Untersuchungen über Immunität. II. Ueber AbrinDeutsche Medizinische Wochenschrift (1946), 1891
- The Congress of HygieneNature, 1891
- Experimentelle Untersuchungen über Immunität. I. Ueber RicinDeutsche Medizinische Wochenschrift (1946), 1891
- Ueber die phagocytäre Rolle der TuberkelriesenzellenVirchows Archiv, 1888
- Ueber den Kampf der Zellen gegen Erysipel-kokkenVirchows Archiv, 1887