Role of Hepatic Arterial Blood Flow and Hepatic Nerves on Renal Circulation and Function

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Abstract
Renal and hepatic function in dogs were divided into the following experimental groups: Group I: Combined hepatic arterial occlusion and perlarterial nerve crush. Group II: Hepatic periarterial nerve crush alone. Group HI: Hepatic arterial inflow occlusion alone. All Group I died rapidly within 36 hours with massive liver necrosis and anuria. Group n mortality was high with massive liver necrosis as a major cause of death; in the survivors, in addition to derangements in hepatic function, there was a significant and progressive fall in glomerular filtration rate during the 3 days following operation and in the survivors there was only a very slow and incomplete return to normal over the subsequent 4 weeks. In Group III, in which only the hepatic arteries had been ligated and transected, the survival rate was better than either of the 2 preceding groups and any renal changes observed in the survivors were much less than in either of the 2 groups in which periarterial nerve crush has been carried out with and without ligation of the hepatic artery. These results have been discussed in relation to the hepatorenal syndrome without attempting to relate at this time these highly significant pathophysiologic observations to disease processes in man.

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