Disproportionate Growth in Offspring of Manganese-Deficient Rats

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Abstract
Growth of long bones was studied in offspring of normal and manganese-deficient rats by measuring the length of radius, ulna, tibia, and fibula, as well as body length, in alizarin-stained preparations of animals from birth to 32 days of age and in adult animals from roentgenograms. Body lengths of deficient offspring were consistently shorter than normal. Each of the long bones measured was strikingly shorter than normal in the deficient offspring at birth, both in terms of absolute length, and in terms of bone length relative to body length. From three or 4 days of age to about 16 days of age, the growth of these bones relative to body length appeared to be the same in the two groups. After 16 days of age, the deficient animals again showed a marked decrease in the length of the long bones relative to body length. The radii and tibias of deficient rats were greatly thickened and distorted in shape as compared with the controls. In most cases, a curvature of the radius was seen.

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