STUDIES ON THE PHYSIOLOGY OF MANGANESE IN THE RAT

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Abstract
Synthetic rations with varying Ca/P ratios provided only 57 per day of Mn. Rats raised on these rations exhibited impaired growth, more pronounced in cases where a high Ca/P ratio was present. Mn deficient rats formed less bone, averaging 5% less ash, and 15% less ash/unit vol.; Ca and P in the ash were unchanged. A slight progressive anemia was noted in the deficient animals, with Hb conc. averaging about 2 g./l00 cc. of blood below normal. Hb regeneration decreased. Paired feeding trials showed the same differences in growth, bone, and hemoglobin as in animals fed ad lib. No differences in bone phosphatases were found, but a 2-3-fold increase in blood serum phosphatase was present. Concs. of Ca and P in the blood were normal, though a slight decrease in P absorption was noted in deficient animals. No differences could be found in N metabolism or basal metabolic rate. Ant. pituitary extracts stimulated growth of deficient animals for short periods.