Benzyl Alcohol Attenuates the Pain of Lidocaine Injections and Prolongs Anesthesia

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Abstract
Benzyl alcohol is reported to be painless on injection and to provide limited dermal anesthesia. Benzyl alcohol has also been recommended as an adjuvant to lidocaine to reduce lidocaine's injection pain. There is insufficient data on pain of injection and duration of anesthesia for lidocaine containing benzyl alcohol. We conducted a randomized, placebo-controlled, double-blinded comparison of intradermal 1% lidocaine with 0.86% benzyl alcohol and plain 1% lidocaine for pain of injection and duration of anesthesia. Twenty subjects received the above two agents plus normal saline with and without 0.9% benzyl alcohol, with all solutions adjusted to 375 +/- 13 mosm/L. Lidocaine containing benzyl alcohol was 27% less painful upon injection and provided anesthesia 29% longer than plain lidocaine. Benzyl alcohol is itself an effective anesthetic and can reduce the pain of injection for lidocaine without adversely affecting its anesthetic properties.

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