Diabetes Insipidus Associated with Wegener's Granulomatosis Successfully Treated with Cyclophosphamide

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Abstract
WEGENER'S granulomatosis, a necrotizing granulomatous vasculitis that involves the paranasal sinuses, lungs and glomeruli, rarely involves the brain parenchyma.1 Central-nervous-system involvement is nearly always manifested by cerebral-artery vasculitis, cranial-nerve palsy or opticnerve dysfunction.2 , 3 Before the use of cytotoxic therapy for the disorder, three cases of diabetes insipidus associated with Wegener's granulomatosis were reported.4 5 6 The present report describes a patient with the disorder who had diabetes insipidus and hyperprolactinemia and who was successfully treated with cyclophosphamide.Case ReportIn June, 1974, a 25-year-old man noted the gradual onset of polyuria and polydipsia, with daily urine output of 12 liters. In March, . . .

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