UCN-01 Abrogates G2 Arrest through a Cdc2-dependent Pathway That Is Associated with Inactivation of the Wee1Hu Kinase and Activation of the Cdc25C Phosphatase
Open Access
- 1 December 1998
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 273 (50) , 33455-33464
- https://doi.org/10.1074/jbc.273.50.33455
Abstract
No abstract availableKeywords
This publication has 59 references indexed in Scilit:
- Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint KinaseScience, 1997
- UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53JNCI Journal of the National Cancer Institute, 1996
- rad -Dependent Response of the chk1 -Encoded Protein Kinase at the DNA Damage CheckpointScience, 1996
- Principles of CDK regulationNature, 1995
- The Protein Kinase C Inhibitor Ilmofosine (BM 41 440) Arrests Cells in G2 Phase and Suppresses CDC2 Kinase Activation Through a Mechanism Different from That of DNA Damaging AgentsBiochemical and Biophysical Research Communications, 1994
- Dephosphorylation of human p34cdc2 kinase on both Thr‐14 and Tyr‐15 by human cdc25B phosphataseFEBS Letters, 1993
- Inactivation of the p34
cdc2
-Cyclin B Complex by the Human WEE1 Tyrosine KinaseScience, 1992
- The cdc25 M-phase inducer: An unconventional protein phosphataseCell, 1992
- Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinaseNature, 1991
- Analysis of Events Associated With Cell Cycle Arrest at G2 Phase and Cell Death Induced by CisplatinJNCI Journal of the National Cancer Institute, 1990