Forebrain control of fluid and electrolyte homeostasis and angiotensin sensitivity in rabbit

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Abstract
Rabbits subjected to electrolytic lesion of the AV3V [anterior ventral third ventricle] exhibited expanded plasma volume and plasma Na concentration, and significantly attenuated pressor responses to angiotensin II and hypertonic NaCl solutions injected via the lateral ventricles. Resting arterial pressure, plasma K concentration, extracellular fluid volume, and pressor responses to i.v. angiotensin II were not changed by lesioning. The effects of AV3V lesions in rabbits are similar, but not identical, to those previously observed in rats. Rabbits should be a suitable species in which to carry out studies aimed at distinguishing central and peripheral cardiovascular effects of angiotensin II.

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