Restrictions among heavy and light chain determinants of granulocyte-specific antinuclear factors.

  • 1 July 1972
    • journal article
    • Vol. 23  (1) , 53-60
Abstract
In fifty-five rheumatoid arthritis sera with positive granulocyte-specific antinuclear factors (GS-ANF) tests were made to further characterize these antibodies. All sera contained GS-ANF of the IgG class and most of the sera also of the IgM and IgA classes, whereas only about 10 per cent of the sera contained GS-ANF of the IgD class. Most of the sera contained GS-ANF carrying both κ and λ light chain determinants, but in five cases only one of the light chain subclasses could be found.