A new procedure for the determination of transferrinC (TfC) subtypes by isoelectric focusing

1 July 1980

journal article
research article
Published by Springer Nature in Human Genetics

Vol. 55 (1) , 111-114
https://doi.org/10.1007/bf00329135

Abstract

Isoelectric focusing (IEF) is widely used for the determination of serum protein polymorphisms in forensic investigations. Because of non-genetic heterogeneity of some proteins and of protein-ligand dissociation observed after IEF standardization of procedures is necessary. In this article the authors point out the main difficulties encountered in studying the transferrin subtype polymorphism and describe a new and sensitive method. Two new Tf^C subtypes were observed: Tf^C4 in North American, Bolivian and Brazilian Indians, Tf^C5 in Black Americans, both with polymorphic allele frequencies. In a Pyrenean population the allele frequencies for Tf^C1, Tf^C2 and Tf^C3 were quite similar to those observed in a German population sample.

Keywords

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