The effect of X-radiation on the spermatogenesis of the Guinea-pig

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Abstract
Giant spermatids are formed as a result of irradiation. These may be due to coalescence of 2 or more spermatids to form 1 giant with multiple centrosomes and tails or false spermatids which are spermatocytes in which the nucleus is spermatid in form but secretion of the acrosome has been effected. Inability to undergo mitosis does not lead to immediate death since many spermatocytes, unable to divide, may yet proceed to acrosome formation, and other preliminary stages of spermateleosis. It would seem that the inability of the cell to divide after irradiation is due to the breaking down of some lipoid substance situated in the cortex of the sphere (Golgi apparatus). Sometimes after x-rays this Golgi lipoid cortex becomes flocculent and granular, but a more common finding was that the Golgi bodies failed to reassemble at the formation of the spermatid nucleus. Little abnormality could be seen in the Cavia spermatozoa. In Lepisma the tail elongates but the nucleus remains spherical and the head centrosome fails to make contact with it. There is no evidence that either the vacuolar system or centrosomes are radia-sensitive.

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