Effects of Prostaglandins and Their Methylated Analogues upon Human Adenylate Cyclase in the Upper Gastrointestinal Tract
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in Digestion
- Vol. 17 (6) , 547-553
- https://doi.org/10.1159/000198161
Abstract
The effects of prostaglandin E2, prostaglandin A2 and their methylated analogues upon the adenylate cyclase in human gastric mucosa were studied. PG E2 and 16,16-dimethyl-PG E2 stimulated the enzyme activity to a greater degree than PG A2 and 16, 16-dimethyl-PG A2. 16, 16-dimethyl-PG E2 was less potent in activating the enzyme system than its parent compound. The results suggest that the more pronounced antisecretory activity of 16, 16-dimethyl-PG E2 is due to its greater resistance against enzymatic degradation.Keywords
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