siVirus: web-based antiviral siRNA design software for highly divergent viral sequences

Open Access

1 July 2006

journal article
research article
Published by Oxford University Press (OUP) in Nucleic Acids Research

Vol. 34 (Web erver) , W448-W450
https://doi.org/10.1093/nar/gkl214

Abstract

SiVirus ( http://siVirus.RNAi.jp/ ) is a web-based online software system that provides efficient short interfering RNA (siRNA) design for antiviral RNA interference (RNAi). siVirus searches for functional, off-target minimized siRNAs targeting highly conserved regions of divergent viral sequences. These siRNAs are expected to resist viral mutational escape, since their highly conserved targets likely contain structurally/functionally constrained elements. siVirus will be a useful tool for designing optimal siRNAs targeting highly divergent pathogens, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza virus and SARS coronavirus, all of which pose enormous threats to global human health.

Keywords

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